CADHERIN INTERCELLULAR-ADHESION MOLECULE IN HEPATOCELLULAR CARCINOMAS - LOSS OF E-CADHERIN EXPRESSION IN AN UNDIFFERENTIATED CARCINOMA

被引：189

作者：

SHIMOYAMA, Y ^{[1
]}

HIROHASHI, S ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT SURG,TOKYO 108,JAPAN

来源：

CANCER LETTERS | 1991年 / 57卷 / 02期

关键词：

CADHERIN; INTERCELLULAR ADHESION; HEPATOCELLULAR CARCINOMA; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0304-3835(91)90206-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of E- and P-cadherin in 24 primary hepatocellular carcinomas, together with the non-cancerous liver tissue from each case, was examined by immunohistochemical staining. Cells of 23 grade I-III carcinomas as well as hepatocytes in all the non-cancerous livers expressed E-cadherin at the cell-cell boundary and showed tight intercellular adhesion without exception. However, a highly undifferentiated carcinoma classified as grade IV apparently lacked E-cadherin expression and also showed decreased intercellular adhesiveness. Loss of E-cadherin expression may be one of the characteristics of highly undifferentiated hepatocellular carcinoma. In contrast to E-cadherin, P-cadherin was never detected in either the cancer cells or non-cancerous hepatocytes in all cases.

引用

页码：131 / 135

页数：5

共 19 条

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