NERVE GROWTH AND FACTOR LEVELS IN DEVELOPING RAT SKIN - UP-REGULATION FOLLOWING SKIN WOUNDING

被引：70

作者：

CONSTANTINOU, J ^{[1
]}

REYNOLDS, ML ^{[1
]}

WOOLF, CJ ^{[1
]}

SAFIEHGARABEDIAN, B ^{[1
]}

FITZGERALD, M ^{[1
]}

机构：

[1] UCL, DEPT ANAT & DEV BIOL, LONDON WC1E 6BT, ENGLAND

来源：

NEUROREPORT | 1994年 / 5卷 / 17期

关键词：

NERVE GROWTH FACTOR; SENSORY NEURONS; SKIN; WOUND; SYMPATHETIC NEURON; CUTANEOUS INNERVATION;

D O I：

10.1097/00001756-199411000-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LEVELS of nerve growth factor (NGF) in rat hindpaw skin, measured with a sensitive two-site enzyme-linked immunosorbent assay, show two peaks during normal development. The first (57 +/- 5 pg mg(-1)) occurs at embryonic days (E) 18-20 and coincides with the arrival of axon terminals into the hindpaw skin. The second, larger peak (132 +/- 10 pg mg(-1)), occurs later, around postnatal day (P) 21 and may be involved in maintenance of neuronal phenotype. Levels outside the two peaks stay relatively constant throughout development (30 pg mg(-1)). Skin wounding at birth produces a marked increase in NGF levels (149 +/- 25 pg mg(-1)) which declines after 4 days. This large increase is not observed if wounding is performed at older ages and may underlie the sensory hyperinnervation that accompanies neonatal wounds.

引用

页码：2281 / 2284

页数：4

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