INTERLEUKIN-6 PRODUCTION BY DRAINING LYMPH-NODE CELLS FOLLOWING PRIMARY CONTACT SENSITIZATION OF MICE - RELATIONSHIP TO THE PROLIFERATIVE RESPONSE

被引：22

作者：

HOPE, JC ^{[1
]}

DEARMAN, RJ ^{[1
]}

DEBICKI, RJ ^{[1
]}

KIMBER, I ^{[1
]}

HOPKINS, SJ ^{[1
]}

机构：

[1] ZENECA CENT TOXICOL LAB,MACCLESFIELD,CHESHIRE,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 103卷 / 04期

关键词：

INTERLEUKIN-6; CONTACT SENSITIVITY; LYMPH NODE CELL PROLIFERATION;

D O I：

10.1159/000236657

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-6 (IL-6) production and proliferative responses by draining lymph node cells were studied in mice exposed topically to a series of chemicals. Chemicals with the capacity to induce sensitisation, but not non-sensitisers, promoted both IL-6 production and lymph node cell proliferation ex vivo. The responses exhibited similar kinetics, were dependent upon the dose of topically applied allergen, and correlated significantly. We demonstrate that the main source of IL-6 within draining lymph nodes is not proliferating T lymphocytes. The induction of a strong IL-6 response, and the relationship of this to cellular proliferation indicate that production of this cytokine within the lymph node is closely associated with the induction of contact sensitivity in mice.

引用

页码：378 / 383

页数：6

共 27 条

[1] PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].