ELECTRICAL FIELDS, NERVE GROWTH AND NERVE REGENERATION

被引：88

作者：

MCCAIG, CD

RAJNICEK, AM

机构：

来源：

EXPERIMENTAL PHYSIOLOGY | 1991年 / 76卷 / 04期

基金：

英国惠康基金;

关键词：

SPINAL-CORD INJURY; DISPERSED CELL-CULTURE; XENOPUS MUSCLE-CELLS; HIPPOCAMPAL-NEURONS; NEURITE GROWTH; CURRENTS LEAVE; GUINEA-PIG; ADULT-RAT; ACETYLCHOLINE-RECEPTORS; PRIMITIVE STREAK;

D O I：

10.1113/expphysiol.1991.sp003514

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The presence of voltage gradients within developing and damaged tissues led to the notion that the resultant electrical fields provide instructional cues to cells. Field effects on avian and amphibian neurones in vitro include increased differentiation, turning of neurites towards the cathode, increased rate of growth towards the cathode, resorption of anodefacing neurites, increased branching and increased filopodial activity. Electric fields enhance regeneration of damaged PNS and CNS neurones in animals as diverse as lampreys, frogs, rats and guinea‐pigs, but the mechanisms by which fields produce their effects are not understood. Further examination of the interaction of fields with intracellular elements, such as the cytoskeleton and second messenger systems, may offer some insight. © 1991 The Physiological Society

引用

页码：473 / 494

页数：22

共 104 条

[1] GROWTH AND CONNECTIVITY OF AXOTOMIZED RETINAL NEURONS IN ADULT-RATS WITH OPTIC NERVES SUBSTITUTED BY PNS GRAFTS LINKING THE EYE AND THE MIDBRAIN [J].