VASOACTIVE EFFECTS OF INTRAVASCULAR AND EXTRAVASCULAR SEROTONIN, PGE2 AND PGF2-ALPHA IN HUMAN UMBILICAL ARTERIES

被引：20

作者：

HAUGEN, G ^{[1
]}

BJORO, K ^{[1
]}

STRAYPEDERSEN, S ^{[1
]}

机构：

[1] UNIV OSLO,NATL HOSP,INST CLIN BIOCHEM,OSLO 3,NORWAY

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1991年 / 31卷 / 04期

关键词：

PERFUSION; PGE2; PGF2-ALPHA; SEROTONIN; UMBILICAL ARTERY; ENDOTHELIUM;

D O I：

10.1159/000293160

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The effect of serotonin, PGE2 and PGF2-alpha on the vascular tension in human umbilical arteries has been investigated during in vitro perfusions. All autacoids induced dose-dependent biphasic pressure responses when added to the perfusate. When added to the extraumbilical fluid, serotonin induced monophasic vasoconstrictory responses, whereas PGE2 and PGF2-alpha did not elicit significant changes except for minor pressure oscillations in some experiments. The results obtained suggest a contributory role of the endothelial layer in the action of these autacoids on the smooth muscle tension.

引用

页码：208 / 212

页数：5

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