HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CIPROFLOXACIN IN PLASMA

被引：19

作者：

MEHTA, AC

HARTDAVIES, S

KAY, EA

机构：

[1] Department of Pharmacy, General Infirmary, Leeds, Yorkshire

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1992年 / 17卷 / 02期

关键词：

D O I：

10.1111/j.1365-2710.1992.tb01278.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper describes an accurate, specific and sensitive high-performance liquid chromatographic (HPLC) method for the determination of ciprofloxacin in small samples (0.5 ml). The samples, after pretreatment by solvent extraction, were eluted on a reversed-phase column and detected by an ultraviolet detector. The results obtained on patient samples are presented.

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页码：117 / 120

页数：4

相关论文

共 10 条

[1]

BORNER K, 1986, J CLIN CHEM CLIN BIO, V24, P325

[2]

BORNER K, 1990, ANAL DRUGS METABOLIT, P131

[3] RAPID HPLC ASSAY OF FLUOROQUINOLONES IN CLINICAL SPECIMENS [J].

CHAN, CY ;

LAM, AW ;

FRENCH, GL .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 23 (04) :597-604

[4] A DIRECT LIQUID-CHROMATOGRAPHIC QUANTITATION OF CIPROFLOXACIN IN MICROSAMPLES OF PLASMA WITH FLUOROMETRIC DETECTION [J].

ELYAZIGI, A ;

ALRAWITHY, S .

THERAPEUTIC DRUG MONITORING, 1990, 12 (04) :378-381

[5] DETERMINATION OF CIPROFLOXACIN (BAY O 9867) IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GAU, W ;

PLOSCHKE, HJ ;

SCHMIDT, K ;

WEBER, B .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1985, 8 (03) :485-497

[6] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CIPROFLOXACIN IN BIOLOGICAL-FLUIDS [J].

JEHL, F ;

GALLION, C ;

DEBS, J ;

BROGARD, JM ;

MONTEIL, H ;

MINCK, R .

JOURNAL OF CHROMATOGRAPHY, 1985, 339 (02) :347-357

[7] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF ANTIBIOTICS [J].

JEHL, F ;

GALLION, C ;

MONTEIL, H .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 531 :509-548

[8]

NIX DE, 1985, CLIN CHEM, V31, P684

[9]

SMITH JM, 1988, BR J PHARM PACT, V10, P18

[10] QUANTITATION OF CIPROFLOXACIN IN BODY-FLUIDS BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].

WEBER, A ;

CHAFFIN, D ;

SMITH, A ;

OPHEIM, KE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (04) :531-534