COMPARATIVE EFFECTS OF IMIPRAMINE AND DOTHIEPIN ON SALIVARY RATE IN NORMAL VOLUNTEERS

1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross‐over, double‐blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross‐over treatment periods. However, pooled observations from the initial and cross‐over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance. 1979 The British Pharmacological Society