PASTEURELLA-HAEMOLYTICA-A1 AND BOVINE RESPIRATORY-DISEASE - PATHOGENESIS

被引:142
作者
WHITELEY, LO [1 ]
MAHESWARAN, SK [1 ]
WEISS, DJ [1 ]
AMES, TR [1 ]
KANNAN, MS [1 ]
机构
[1] UNIV MINNESOTA, COLL VET MED, DEPT CLIN & POPULAT SCI, ST PAUL, MN 55108 USA
关键词
D O I
10.1111/j.1939-1676.1992.tb00980.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The severe fibrinonecrotic pneumonia associated with pneumonic pasteurellosis usually results from colonization of the lower respiratory tract by Pasteurella haemolytica biotype A, serotype 1(A1). Despite recent research efforts, the authors lack a detailed understanding of the interactions and host response to P. haemolytica in the respiratory tract. The authors hypothesize that management and environmental stress factors or viral infection alters the upper respiratory tract (URT) epithelium allowing P. haemolytica to colonize the epithelium. Once the URT is colonized, large numbers of organisms enter the lung where they interact with alveolar macrophages. Endotoxin, released from the bacteria, crosses the alveolar wall where it activates pulmonary intravascular macrophages, endothelium, neutrophils, lymphocytes, platelets, complement, and Hageman factor leading to complex interactions of cells and mediators. It is the progression of this inflammatory response with neutrophil influx that is ultimately responsible for the pulmonary injury. Leukotoxin is a major virulence factor of P. haemolytica that allows it to survive by destroying phagocytic cells. At subcytolytic concentrations it may also enhance the inflammatory response by activating cells to produce mediators and release reactive oxygen metabolites and proteases.
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页码:11 / 22
页数:12
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