EFFECTS OF PROTEASE INHIBITORS ON GROWTH OF SERRATIA-MARCESCENS AND PSEUDOMONAS-AERUGINOSA

被引：19

作者：

MIYAGAWA, SI

NISHINO, N

KAMATA, R

OKAMURA, RI

MAEDA, H

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT MICROBIOL,KUMAMOTO 860,JAPAN

[2] KUMAMOTO UNIV,SCH MED,DEPT OPHTHALMOL,KUMAMOTO 860,JAPAN

[3] KYUSHU INST TECHNOL,KITAKYUSHU 804,JAPAN

来源：

MICROBIAL PATHOGENESIS | 1991年 / 11卷 / 02期

关键词：

SERRATIA-MARCESCENS; PSEUDOMONAS-AERUGINOSA; OVOMACROGLOBULIN; PROTEASE INHIBITOR; BACTERIAL GROWTH;

D O I：

10.1016/0882-4010(91)90007-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The growth inhibitory effects of chicken egg white ovomacroglobulin (ovoM) on Serratia marcescens and Pseudomonas aeruginosa were studied. The growth of protease-producing strains was greater than that of the strains producing little protease, and was inhibited in a dose-dependent manner by ovoM, a potent protease inhibitor. Dose-dependent enhancement of growth of strains of S. marcescens and P. aeruginosa that produce little protease was observed with the medium treated with proteases. These results indicate that extracellular proteases produced by the organisms augment their growth and that inhibition of the proteases results in suppression of growth. © 1991.

引用

页码：137 / 141

页数：5

共 22 条

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[2] BACTERIAL-GROWTH BLOCKED BY A SYNTHETIC PEPTIDE BASED ON THE STRUCTURE OF A HUMAN PROTEINASE-INHIBITOR [J].