DOSE-RELATED INCREASE OF HDL-CHOLESTEROL LEVELS AFTER N-ACETYLCYSTEINE IN MAN

被引：17

作者：

FRANCESCHINI, G

WERBA, JP

SAFA, O

GIKALOV, I

SIRTORI, CR

机构：

[1] UNIV MILAN,INST PHARMACOL SCI,CTR E GROSSI PAOLETTI,VIA BALZARETTI 9,I-20133 MILAN,ITALY

[2] SIEGFRIED PHARMA LTD,ZOFINGEN,SWITZERLAND

来源：

PHARMACOLOGICAL RESEARCH | 1993年 / 28卷 / 03期

关键词：

LIPOPROTEIN(A); HDL-CHOLESTEROL; N-ACETYLCYSTEINE;

D O I：

10.1006/phrs.1993.1124

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system. © 1993 The Italian Pharmacological Society.

引用

页码：213 / 218

页数：6

共 29 条

[1] EFFECT OF HELP-LDL-APHERESIS ON SERUM CONCENTRATIONS OF HUMAN LIPOPROTEIN(A) - KINETIC-ANALYSIS OF THE POST-TREATMENT RETURN TO BASELINE LEVELS [J].