INHIBITION OF OXYTOCIN-DRIVEN OR PROSTAGLANDIN F2-ALPHA-DRIVEN MYOMETRIAL ACTIVITY BY RELAXIN IN THE RAT IS ESTROGEN-DEPENDENT

被引：24

作者：

PORTER, DG ^{[1
]}

DOWNING, SJ ^{[1
]}

BRADSHAW, JMC ^{[1
]}

机构：

[1] UNIV BRISTOL, SCH MED, DEPT ANAT, BRISTOL BS8 1TD, AVON, ENGLAND

来源：

JOURNAL OF ENDOCRINOLOGY | 1981年 / 89卷 / 03期

关键词：

D O I：

10.1677/joe.0.0890399

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relaxin in doses of 5 .mu.g i.v. completely but reversibly abolishes spontaneous myometrial activity in anesthetized ovariectomized rats. Similar levels of myometrial activity, evoked in estrogen-treated rats (which normally have quiescent uteri) by infusions of oxytocin or prostaglandin[PG]F2.alpha. were also reduced to complete quiescence by relaxin in small doses. When spontaneous myometrial activity in untreated ovariectomized rats was slightly stimulated by oxytocin, the uterus became completely refractory to the inhibitory effects of relaxin even at doses of 50 .mu.g. Relaxin was also ineffective in reducing myometrial activity in similar rats during intra-arterial infusion of PGF2.alpha.. The ability of relaxin to inhibit uterine smooth muscle during exogenous stimulation is apparently estrogen-dependent.

引用

页码：399 / 404

页数：6

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