DISTRIBUTION OF HLA-ANTIGENS IN GERMAN PATIENTS WITH IDIOPATHIC HEMOCHROMATOSIS

被引：5

作者：

DYRSZKA, H ^{[1
]}

EBERHARDT, G ^{[1
]}

ECKERT, G ^{[1
]}

机构：

[1] HANOVER UNIV MED,KLIN IMMUNOL & TRANSFUS MED ABT,D-3000 HANOVER,FED REP GER

来源：

KLINISCHE WOCHENSCHRIFT | 1979年 / 57卷 / 10期

关键词：

HLA-antigens; Idiopathic hemochromatosis;

D O I：

10.1007/BF01487823

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HLA-phenotypes were determined in 31 (30 unrelated) patients with hemochromatosis and compared to the distribution of HLA-antigens in the general German population. A significant excess of HLA-A3 was observed (76.7% vs. 30.2%). The frequency of HLA-B7 was also increased (53.3% vs. 27.0%). However, the difference did not quite reach the level of statistical significance, when correction for multiple comparisons was made. Our finding are in accord with previous observations for different ethnic groups, indicating an association of IH with the A3/B7 haplotype. © 1979 Springer-Verlag.

引用

页码：529 / 531

页数：3

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