ORIGIN OF THE EXTRA CHROMOSOME IN TRISOMY 21

被引：51

作者：

MATTEI, JF

MATTEI, MG

AYME, S

GIRAUD, F

机构：

[1] Centre de Génétique Médicale, Hôpital d'Enfants de la Timone, Marseille Cedex 4

来源：

HUMAN GENETICS | 1979年 / 46卷 / 01期

关键词：

D O I：

10.1007/BF00278908

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Of 61 families of children with trisomy 21, polymorphism of chromosome 21 elucidating the origin of the extra chromosome was found in 42. Nondisjunction was of paternal origin in 8 cases (19.04%) and the anomaly occurred with equal frequency during the first and second meiotic divisions. Maternal nondisjunction was demonstrated in 34 cases (80.95%), in which nondisjunction occurred by far the most often during the first meiotic division (29 cases). These results are in agreement with data from the literature, and suggest the existence of at least two different causes for chromosomal nondisjunction, the first being the same in both sexes and occurring in both meiotic divisions and the second specifically limited to the first meiotic division in the mother. © 1979 Springer-Verlag.

引用

页码：107 / 110

页数：4

共 18 条

[1]

CASPERSSON T, 1970, CHROMOSOMA, V30, P215

[2]

DUTRILLAUX B, 1971, CR ACAD SCI D NAT, V272, P2638

[3]

GIRAUD F, 1975, LYON MED, V233, P241

[4]

GIRAUD F, 1975, J GENET HUM S1

[5]

GROUCHY JD, 1970, ANN GENET-PARIS, V13, P52

[6] ORIGIN OF HUMAN TRISOMICS AND POLYPLOIDS [J].

JACOBS, PA ;

MORTON, NE .

HUMAN HEREDITY, 1977, 27 (01) :59-72

[7]

LANGENBECK U, 1976, HUM GENET, V33, P89

[8]

LICZNERSKI G, 1972, HEREDITAS-GENETISK A, V70, P153

[9] PARENTAL ORIGIN OF EXTRA CHROMOSOME IN DOWNS-SYNDROME [J].

MAGENIS, RE ;

OVERTON, KM ;

CHAMBERLIN, J ;

BRADY, T ;

LOVRIEN, E .

HUMAN GENETICS, 1977, 37 (01) :7-16

[10] MATERNAL AND PATERNAL ORIGIN OF EXTRA CHROMOSOME IN TRISOMY 21 [J].

MIKKELSEN, M ;

HALLBERG, A ;

POULSEN, H .

HUMAN GENETICS, 1976, 32 (01) :17-21

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