FATE OF 3-PHENOXYBENZALDEHYDE - DIPHENYL ETHER CLEAVAGE, A MAJOR METABOLIC ROUTE IN CHICKEN

The fate of 3-phenoxybenzaldehyde was investigated in chicken after oral administration of the unlabeled compound for 3 days, followed by a single dose of ald-14C-labeled material. Approximately 98 % of the administered radiocarbon was eliminated within 24 h. Radiocarbon metabolites were excreted free as well as conjugated. Free metabolites identified in excreta were 3-hydroxybenzoic acid (8%), 3-phenoxybenzoic acid (5%), and 2- and/or 4-hydroxy-3-phenoxybenzoic acid (traces,<1%). Only a small amount (8%) of 3-hydroxybenzoic acid was eliminated as glucuronic acid and sulfate conjugates. Hydrolysis of the polar metabolites with 2 N HCl produced 37-42 % 3-hydroxybenzoic acid. Similarly, 3-hydroxybenzoic acid (both free and conjugates) was also detected in the excreta of hens fed deltamethrin or fenvalerate. The diphenyl ether cleavage of 3-phenoxybenzaldehyde is a major route, probably via 3-phenoxybenzoic acid, in chickens. © 1990, American Chemical Society. All rights reserved.