EFFECT OF AZIDOTHYMIDINE (AZT) ON HIV P24 ANTIGEN, BETA-2-MICROGLOBULIN, NEOPTERIN, SOLUBLE CD8, SOLUBLE INTERLEUKIN-2 RECEPTOR AND TUMOR NECROSIS FACTOR-ALPHA LEVELS IN PATIENTS WITH AIDS-RELATED COMPLEX OR AIDS

被引：18

作者：

REDDY, MM

MCKINLEY, G

ENGLARD, A

GRIECO, MH

机构：

[1] R.A. Cooke Institute of Allergy, St Luke's - Roosevelt Hospital Center New York, NY

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1990年 / 12卷 / 07期

关键词：

D O I：

10.1016/0192-0561(90)90036-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circulating HIV P24 antigen, beta2-microglobulin, neopterin, soluble CD8, soluble interleukin-2 receptor and TNF alpha levels were measured in 20 patients (9 with ARC and 11 with AIDS) treated with azidothymidine (AZT) and in 12 patients (3 with ARC and 9 with AIDS) who were in a placebo group. Mean levels of HIV P24 antigen, beta2-microglobulin, neopterin and SCD8 decreased significantly (P<0.05) after 12 to 16 weeks of AZT administration. SIL-2R and TNF alpha serum levels did not appear to change in association with AZT therapy. No changes were observed in the placebo group except that TNF alpha levels appeared to increase after 12 to 16 weeks. These results suggest that AZT administration may have led to reduced HIV P24 antigen, beta2-microglobulin, neopterin and SCD8 mean levels in these patients. © 1990.

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收藏

页码：737 / 741

页数：5

相关论文

共 18 条

[1]

BARTLETT JA, 1988, JAMA-J AM MED ASSOC, V260, P3051

[2] SURVIVAL EXPERIENCE AMONG PATIENTS WITH AIDS RECEIVING ZIDOVUDINE - FOLLOW-UP OF PATIENTS IN A COMPASSIONATE PLEA PROGRAM [J].

CREAGHKIRK, T ;

DOI, P ;

ANDREWS, E ;

NUSINOFFLEHRMAN, S ;

TILSON, H ;

HOTH, D ;

BARRY, DW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 260 (20) :3009-3015

[3] TUMOR NECROSIS FACTOR A ACTIVATES HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 THROUGH INDUCTION OF NUCLEAR FACTOR BINDING TO THE NF-KAPPA-B SITES IN THE LONG TERMINAL REPEAT [J].

DUH, EJ ;

MAURY, WJ ;

FOLKS, TM ;

FAUCI, AS ;

RABSON, AB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5974-5978

[4] THE HUMAN IMMUNODEFICIENCY VIRUS - INFECTIVITY AND MECHANISMS OF PATHOGENESIS [J].

FAUCI, AS .

SCIENCE, 1988, 239 (4840) :617-622

[5] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[6] TUMOR NECROSIS FACTOR-ALPHA INDUCES EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS IN A CHRONICALLY INFECTED T-CELL CLONE [J].

FOLKS, TM ;

CLOUSE, KA ;

JUSTEMENT, J ;

RABSON, A ;

DUH, E ;

KEHRL, JH ;

FAUCI, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2365-2368

[7] NEOPTERIN AS A MARKER FOR ACTIVATED CELL-MEDIATED-IMMUNITY - APPLICATION IN HIV INFECTION [J].

FUCHS, D ;

HAUSEN, A ;

REIBNEGGER, G ;

WERNER, ER ;

DIERICH, MP ;

WACHTER, H .

IMMUNOLOGY TODAY, 1988, 9 (05) :150-155

[8] AZIDOTHYMIDINE [J].

HIRSCH, MS .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (03) :427-431

[9] HUMAN IMMUNODEFICIENCY VIRUS (HIV) ANTIGENEMIA (P24) IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND THE EFFECT OF TREATMENT WITH ZIDOVUDINE (AZT) [J].

JACKSON, GG ;

PAUL, DA ;

FALK, LA ;

RUBENIS, M ;

DESPOTES, JC ;

MACK, D ;

KNIGGE, M ;

EMESON, EE .

ANNALS OF INTERNAL MEDICINE, 1988, 108 (02) :175-180

[10] SERUM BETA-2-MICROGLOBULIN DECREASES IN PATIENTS WITH AIDS OR ARC TREATED WITH AZIDOTHYMIDINE [J].

JACOBSON, MA ;

ABRAMS, DI ;

VOLBERDING, PA ;

BACCHETTI, P ;

WILBER, J ;

CHAISSON, RE ;

CROWE, S ;

HOWARD, W ;

MOSS, A .

JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (06) :1029-1036