GENERATION OF HIGH ANTIMYCOTIC ACTIVITY DURING DEGRADATION OF BETA-LACTAM ANTIBIOTICS

被引：10

作者：

SANYAL, AK

CHOWDHURY, B

BANERJEE, AB

机构：

[1] University College of Science, Department of Biochemistry, Microbiology Laboratory, Calcutta, 700 019

来源：

LETTERS IN APPLIED MICROBIOLOGY | 1992年 / 14卷 / 05期

关键词：

D O I：

10.1111/j.1472-765X.1992.tb00690.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cephalosporins generated antifungal principle(s) during their degradation in aqueous solution though their antibacterial property is lost progressively during this process. The degradation product(s) from cephalexin. cefadroxil cephacetril and cefazolin showed high activity against the dermatophytes of the genus Trichophyton, Microsporum, and Epidermophyton. Growth of a plant pathogen Macrophomina phaseolina was also weakly inhibited. Unlike the cephalosporins none of the penicillins tested produced such an antifungally active substance in aqueous solution. The nature of antimycotic activity generated from cefazolin was different from that produced from cephalexin, cefadroxil and cephacetril.

引用

页码：221 / 223

页数：3

共 4 条

[1] DEGRADATION KINETICS AND MECHANISMS OF A NEW CEPHALOSPORIN, CEFIXIME, IN AQUEOUS-SOLUTION [J].