A COMPARISON OF THE PHARMACODYNAMICS OF ROCURONIUM AND VECURONIUM DURING HALOTHANE ANESTHESIA

被引：49

作者：

BOOTH, MG ^{[1
]}

MARSH, B ^{[1
]}

BRYDEN, FMM ^{[1
]}

ROBERTSON, EN ^{[1
]}

BAIRD, WLM ^{[1
]}

机构：

[1] ROYAL INFIRM,DIV ANAESTHESIA,GLASGOW G31 3ER,SCOTLAND

来源：

ANAESTHESIA | 1992年 / 47卷 / 10期

关键词：

NEUROMUSCULAR RELAXANTS; ROCURONIUM; VECURONIUM; ANESTHETICS; VOLATILE; HALOTHANE;

D O I：

10.1111/j.1365-2044.1992.tb03139.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6mg.kg−1 or vecuronium 0.1 mg.kg−1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train‐of‐four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group. Copyright © 1992, Wiley Blackwell. All rights reserved

引用

页码：832 / 834

页数：3

共 15 条

[1] THE NEUROMUSCULAR BLOCKING EFFECT OF ORG-9426 - A NEW INTERMEDIATELY-ACTING STEROIDAL NONDEPOLARIZING MUSCLE-RELAXANT IN MAN [J].