COMPARATIVE THEORETICAL-STUDY OF THE CONFORMATIONS OF AMPHOTERICIN METHYL-ESTER AND AMPHOTERICIN-B POLAR HEADS IN THE PRESENCE OF WATER

被引：12

作者：

MEDDEB, S ^{[1
]}

BERGES, J ^{[1
]}

CAILLET, J ^{[1
]}

LANGLET, J ^{[1
]}

机构：

[1] UNIV PARIS 06, CNRS 271, TOUR 22, 4 PL JUSSIEU, F-75252 PARIS 05, FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1112卷 / 02期

关键词：

AMPHOTERICIN METHYL ESTER; AMPHOTERICIN-B; CONFORMATION; THEORETICAL STUDY;

D O I：

10.1016/0005-2736(92)90401-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amphotericin methyl ester (AmE) is an interesting derivative of amphotericin B (AmB) because of its enhancement of selectivity against the fungicells. Both AmB and AmE molecules differ by the structure of their polar heads. This work deals with a theoretical study of conformations of the polar head of AmE in the presence of hydration water molecules. The results will be compared with our previous work concerning AmB.

引用

页码：266 / 272

页数：7

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