TAN-1057A, TAN-1057B, TAN-1057C, TAN-1057D, NEW ANTIBIOTICS WITH POTENT ANTIBACTERIAL ACTIVITY AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY

被引：48

作者：

KATAYAMA, N ^{[1
]}

FUKUSUMI, S ^{[1
]}

FUNABASHI, Y ^{[1
]}

IWAHI, T ^{[1
]}

ONO, H ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,PHARMACEUT RES LABS 3,DIV PHARMACEUT RES,OSAKA 532,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 04期

关键词：

D O I：

10.7164/antibiotics.46.606

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.

引用

页码：606 / 613

页数：8

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