EFFECT OF ZINC-SULFATE AND ACETYLCYSTEINE ON EXPERIMENTAL GASTRIC-ULCER - INVITRO STUDY

被引：13

作者：

MANN, NS

MANN, SK

BRAWN, PN

WEAVER, B

机构：

[1] TEXAS A&M UNIV SYST,COLL MED,DEPT MED,TEMPLE,TX

[2] TEXAS A&M UNIV SYST,COLL MED,DEPT PATHOL,TEMPLE,TX

[3] VET ADM MED CTR,TEMPLE,TX

来源：

DIGESTION | 1992年 / 53卷 / 1-2期

关键词：

ORGAN CULTURE; INVITRO CHRONIC ULCER; SULFHYDRYL COMPOUNDS; N-ETHYLMALEIMIDE; N-(4-AMINOPHENYL)MALEIMIDE STAIN;

D O I：

10.1159/000200978

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A small ulcer produced in vitro by monopolar electrocoagulation on endoscopically obtained human antral biopsies and incubated in Trowel T-8 medium at 37-degrees-C for 8 h has many histologic features of chronic gastric ulcer in man. Zinc sulfate and acetylcysteine in low concentrations had a significant healing effect in this ulcer model. Since the beneficial effect of zinc sulfate and acetylcysteine was counteracted by N-ethylmaleimide, a known blocker of sulfhydryl compounds, the beneficial effect of these two compounds probably was mediated through sulfhydryl compounds. Using special stain, N-(4-aminophenyl)maleimide, the sulfhydryl groups were localized in the epithelial cells of the surface layer and gastric glands.

引用

页码：108 / 113

页数：6

共 46 条

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