SEQUENCE VARIANTS OF HUMAN PAPILLOMAVIRUS TYPE-16 FROM COUPLES SUGGEST SEXUAL TRANSMISSION WITH LOW INFECTIVITY AND POLYCLONALITY IN GENITAL NEOPLASIA

被引：41

作者：

HO, L

TAY, SK

CHAN, SY

BERNARD, HU

机构：

[1] NATL UNIV SINGAPORE, INST MOLEC & CELL BIOL, PAPILLOMAVIRUS BIOL LAB, SINGAPORE 0511, SINGAPORE

[2] SINGAPORE GEN HOSP, DEPT OBSTET & GYNECOL, SINGAPORE, SINGAPORE

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 168卷 / 04期

关键词：

D O I：

10.1093/infdis/168.4.803

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human papillomavirus type 16 (HPV-16) is causally involved in the pathogenesis of genital neoplasia, but important details of the natural history of infection and disease are not yet understood. Many individual HPV-16 DNA isolates differ by characteristic point mutations. In a study of the HPV-16 variants from genital lesions of 32 married couples, HPV-16 was detected in both the husband and the wife in 8 couples. Of these, 4 demonstrated identical HPV-16 variants between husband and wife, and 4 had mismatching HPV-16 variants. Five of 31 biopsies showed simultaneous presence of two different HPV-16 variants. The data suggest that sexual transmission of HPV-16 does occur, but with low infectivity, and that HPV-16-related premalignant lesions are frequently polyclonal.

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页码：803 / 809

页数：7

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