ORGANOTROPIC FORMATION AND DISAPPEARANCE OF 8-HYDROXYDEOXYGUANOSINE IN THE KIDNEY OF SPRAGUE-DAWLEY RATS EXPOSED TO ADRIAMYCIN AND KBRO3

被引：37

作者：

CHO, DH

HONG, JT

CHIN, K

CHO, TS

LEE, BM

机构：

[1] SUNGKYUNKWAN UNIV, SCH PHARM, DIV TOXICOL, SUWON 440746, SOUTH KOREA

[2] NATL INST SAFETY RES, DEPT TOXICOL, SEOUL 122020, SOUTH KOREA

来源：

CANCER LETTERS | 1993年 / 74卷 / 03期

关键词：

KBRO3; POTASSIUM BROMATES; 8-OHDG; 8-HYDROXYDEOXY-GUANOSINE; HPLC-ECD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-ELECTROCHEMICAL DETECTOR; DG; DEOXYGUANOSINE;

D O I：

10.1016/0304-3835(93)90235-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A form of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was comparatively determined for 48 h in the kidney and liver isolated from Sprague-Dawley rats i.p. treated with Adriamycin; potassium bromate (KBrO3), hydroquinone and vitamin A. HPLC-ECD analysis system showed that Adriamycin and KBrO3, renal carcinogens, induced higher levels of 8-OHdG in the target organ of kidney (12-13.8 residues/10(4) dG(deoxyguanosine)) compared to those in the liver (3.4-3.8 residues/10(4) dG) and showed highly persistent levels (8 residues, 10(4) dG) in the kidney. The data suggest that the organotropic persistence of 8-OHdG may provide a useful marker for identifying target organ systems in oxidative chemical carcinogenesis and screening free radical-generating carcinogens.

引用

页码：141 / 145

页数：5

共 24 条

[1]

Ames B. N., 1985, MOL BIOL AGING GENE, P137

[2] DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES [J].