INCREASED NITRIC-OXIDE PRODUCTION IN HEART-FAILURE

被引：222

作者：

WINLAW, DS

SMYTHE, GA

KEOGH, AM

SCHYVENS, CG

SPRATT, PM

MACDONALD, PS

机构：

[1] ST VINCENTS HOSP,VICTOR CHANG CARDIAC RES INST,DEPT CARDIOPULM TRANSPLANTAT,SYDNEY,NSW 2010,AUSTRALIA

[2] ST VINCENTS HOSP,VICTOR CHANG CARDIAC RES INST,DEPT CHEM PATHOL,SYDNEY,NSW 2010,AUSTRALIA

来源：

LANCET | 1994年 / 344卷 / 8919期

关键词：

D O I：

10.1016/S0140-6736(94)91403-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of nitric oxide in heart failure is unknown. The high-capacity inducible isoform of nitric oxide synthase is present in the myocardium of patients with idiopathic dilated cardiomyopathy. Plasma nitrate, the stable end-product of nitric oxide production, was significantly increased in patients with heart failure compared with normal controls (means 51.3 and 24.6 mu mol/L). Vasodilation caused by increased nitric oxide may compensate for the vasoconstrictor effect of neurohumoral adaptions to heart failure. Alternatively, excess production may be detrimental to the heart by a direct negative inotropic effect.

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收藏

页码：373 / 374

页数：2

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