DNA TUMOR-VIRUS TRANSFORMING PROTEINS AND THE CELL-CYCLE

被引：251

作者：

MORAN, E ^{[1
]}

机构：

[1] COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(05)80342-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies using the transforming proteins of the small DNA tumor viruses point to the role of the E2F cellular transcription factor in regulating cell cycle specific gene expression. The evidence derived suggests that E2F is controlled by the retinoblastoma gene product and related proteins, including their associated cyclins. Studies using DNA tumor virus products further suggest the existence of additional pathways of cell-cycle activation.

引用

页码：63 / 70

页数：8

共 42 条

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