DIHYDROPYRROLIZINE DERIVATIVES FROM UNSATURATED PYRROLIZIDINE ALKALOIDS

被引：150

作者：

MATTOCKS, AR

机构：

[1] Toxicology Research Unit, Medical Research Council Laboratories, Carshalton, Surrey

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 08期

关键词：

D O I：

10.1039/j39690001155

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Methods are described for converting alkaloids having the dehydropyrrolizidine ring, and their N-oxides, to dihydropyrrolizine derivatives, which are also formed as metabolites when the alkaloids are administered to animals. Some properties of these products are described. They behave as pyrrole derivatives, and those which are esters are highly reactive alkylating agents, which are probably responsible for toxic effects of the alkaloids.

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页码：1155 / &

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