STRUCTURE AND EVOLUTION OF THE HORSE ZETA-GLOBIN LOCUS

被引：17

作者：

FLINT, J ^{[1
]}

TAYLOR, AM ^{[1
]}

CLEGG, JB ^{[1
]}

机构：

[1] UNIV OXFORD, JOHN RADCLIFFE HOSP, NUFFIELD DEPT CLIN MED, MRC, MOLEC HAEMATOL UNIT, OXFORD OX3 9DU, ENGLAND

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1988年 / 199卷 / 03期

关键词：

D O I：

10.1016/0022-2836(88)90615-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The equine .zeta. globin gene locus consists of an intact 5'' gene and a truncated 3'' pseudogene (.psi..zeta.) that has only 5'' control sequences and a first exon and intron. Nevertheless, the .psi. .zeta. gene has retained almost perfect homology with its neighbour, presumably by gene conversion. The first introns of both .zeta. and .psi..zeta. genes contain a number of degenerate tandem repeats of a 14 base-pair sequence that has been found in the .zeta. genes of goats and humans and that is related to a family of human minisatellite sequences. Comparisons of sequences flanking the .zeta. and .psi..zeta. genes reveal areas of considerable interspecies homology, which can be explained by a .zeta. gene duplication that pre-dated the mammalian radiation.

引用

页码：427 / 437

页数：11

共 36 条

[1] STRIPES DO NOT A ZEBRA MAKE .1. A CLADISTIC-ANALYSIS OF EQUUS [J].