ANTI-TUMOR ACTIVITY OF PRUMYCIN

被引：16

作者：

OKUBO, S ^{[1
]}

NAKAMURA, N ^{[1
]}

ITO, K ^{[1
]}

MARUMO, H ^{[1
]}

TANAKA, M ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO UNIV,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 04期

关键词：

D O I：

10.7164/antibiotics.32.347

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The antifungal antibiotic, prumycin, was studied for antitumor activity against several tumor systems. It was found to possess potential antitumor activity against a well-established mouse mammary adenocarcinoma in C3H/He mice. It was also active in prolongation of the lifespan of mice bearing P-388 lymphocytic leukemia. Moreover, prumycin did not depress the white blood cell counts in the mouse peripheral blood. However, severe alopecia was observed in mice treated with this agent at dosage levels near the LD50. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：347 / 354

页数：8

共 8 条

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