BIOCONVERSION AND BIOSYNTHESIS OF 16-MEMBERED MACROLIDE ANTIBIOTICS .11. INDUCTION OF THE BIOCONVERSION OF LEUCOMYCINS BY GLUCOSE AND ITS REGULATION BY BUTYRATE

被引：12

作者：

KITAO, C ^{[1
]}

MIYAZAWA, J ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1979年 / 43卷 / 04期

关键词：

D O I：

10.1080/00021369.1979.10863540

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Leucomycin Al (LM AI) was converted to leucomycin As (LM As) by Streptomyces kitasatoensis is glucose-containing medium. On the other hand, butyrate, one of the precursors of the aglycone, repressed the bioconversion of LM Al to As. The role of butyrate has been examined in connection with that of glucose. It was found that the production of the enzyme which catalyzes the acetylation at C-3 of aglycone was induced by glucose, and that the induction was remarkably repressed by butyrate. Cerulenin, a specific inhibitor of fatty acid synthesis, was effectively employed for the bioconversion experiments. © 1979 Taylor & Francis Group, LLC.

引用

页码：833 / 839

页数：7

共 20 条

[1]

DEMAIN AL, 1970, BACTERIOL REV, V34, P1

[2]

DEMAIN AL, 1968, LLOYD, V31, P395

[3] STUDIES ON BIOSYNTHESIS OF BASIC 16-MEMBERED MACROLIDE ANTIBIOTICS, PLATENOMYCINS .4. BIOSYNTHESIS OF PLATENOMYCINS [J].

FURUMAI, T ;

TAKEDA, K ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1975, 28 (10) :789-797

[4] ENZYMATIC-HYDROLYSIS OF CEPHALOSPORIN-C BY AN EXTRACELLULAR ACETYLHYDROLASE OF CEPHALOSPORIUM-ACREMONIUM [J].

HINNEN, A ;

NUESCH, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 9 (05) :824-830

[5] REGULATION OF ANTIBIOTIC PRODUCTION - CATABOLITE INHIBITION AND DUALISTIC EFFECT OF GLUCOSE ON INDOLMYCIN PRODUCTION [J].

HURLEY, LH ;

BIALEK, D .

JOURNAL OF ANTIBIOTICS, 1974, 27 (01) :49-56

[6] BIOCHEMICAL STUDIES ON STREPTOMYCES SIOYAENSIS .I. FORMATION OF SIOMYCIN BY RESTING CELL SYSTEM OF STREPTOMYCES SIOYAENSIS [J].

KIMURA, A .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1967, 31 (07) :837-&

[7]

KIRSCH EJ, 1970, ANTIBIOTICS, V2, P66

[8] CHANGES IN PHENOXAZINONE SYNTHETASE ACTIVITY DURING GROWTH CYCLE OF STREPTOMYCES ANTIBIOTICUS [J].

MARSHALL, R ;

REDFIELD, B ;

KATZ, E ;

WEISSBACH, H .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 123 (02) :317-+

[9] BIOSYNTHETIC STUDIES USING C-13 ENRICHED PRECURSORS ON 16-MEMBERED MACROLIDE ANTIBIOTIC LEUCOMYCIN A3 [J].

OMURA, S ;

NAKAGAWA, A ;

TAKESHIMA, H ;

ATUSMI, K ;

MIYAZAWA, J ;

PIRIOU, F ;

LUKACS, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (22) :6600-6602

[10] STRUCTURE-BIOLOGICAL ACTIVITIES RELATIONSHIPS AMONG LEUCOMYCINS AND THEIR DERIVATIVES [J].

OMURA, S ;

KATAGIRI, M ;

UMEZAWA, I ;

KOMIYAMA, K ;

MAEKAWA, T ;

SEKIKAWA, K ;

MATSUMAE, A ;

HATA, T .

JOURNAL OF ANTIBIOTICS, 1968, 21 (09) :532-&

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