PLASMA 25-HYDROXY-VITAMIN-D IN NORMAL SUBJECTS AND PATIENTS WITH TERMINAL RENAL-FAILURE, ON MAINTENANCE HEMODIALYSIS AND AFTER TRANSPLANTATION

Plasma 25-hydroxy-vitamin D concentration was measured in 40 normal subjects, 19 patients with terminal renal failure, 137 patients who had been on dialysis up to 11 yr and in 17 renal transplant patients. The mean plasma concentration of 25-hydroxy-vitamin D was below normal in patients with terminal renal failure and in patients who had been on maintenance hemodialysis for less than 1 yr. The mean concentration in patients who had been on dialysis for more than 1 yr and in renal transplant patients was normal. The seasonal variation of plasma 25-hydroxy-vitamin D concentration found in the 58 patients on maintenance hemodialysis for more than 2 yr is similar to that reported in normal subjects.