APOPTOSIS IN PANCREATIC ALLOGRAFT-REJECTION - ULTRASTRUCTURAL OBSERVATIONS

被引：10

作者：

KNOOP, M

MCMAHON, RFT

JONES, CJP

HUTCHINSON, IV

机构：

[1] UNIV MANCHESTER,IMMUNOL GRP,MANCHESTER M13 9PL,LANCS,ENGLAND

[2] UNIV MANCHESTER,DEPT PATHOL,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

EXPERIMENTAL PATHOLOGY | 1991年 / 41卷 / 04期

关键词：

PANCREAS TRANSPLANTATION; APOPTOSIS; ALLOGRAFT REJECTION; REJECTION; ALLOGRAFT; TRANSPLANTATION; PANCREAS;

D O I：

10.1016/S0232-1513(11)80099-X

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Transplantation of pancreaticoduodenal allografts in the PVG.RT 1c --> PVG.RT 1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.

引用

页码：219 / 224

页数：6

共 13 条

[1] EXPERIMENTAL PANCREATITIS IN THE RAT - ULTRASTRUCTURE OF SODIUM TAUROCHOLATE-INDUCED PANCREATIC LESIONS [J].