ANTIOXIDANT DEFENSES IN THE GROUND-SQUIRREL CITELLUS-CITELLUS .2. THE EFFECT OF HIBERNATION

被引：100

作者：

BUZADZIC, B

SPASIC, M

SAICIC, ZS

RADOJICIC, R

PETROVIC, VM

HALLIWELL, B

机构：

[1] Department of Biochemistry, University of London King's College, London, WC2R 2LS, Strand Campus

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 05期

关键词：

HIBERNATION; ANTIOXIDANT; IBAT; SOD; GSHPX; CAT; FREE RADICALS;

D O I：

10.1016/0891-5849(90)90017-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In spring and autumn, the ground squirrel Citellus citellus is awake and active but in winter it usually hibernates. Reawakening from hibernation involves intense metabolic activity in the interscapular brown adipose tissue (IBAT). The IBAT of hibernation animals showed significant increases in the activities of superoxide dismutase (both copper-zinc and manganese-containing enzymes), glutathione peroxidase, and in the amount of ascorbate present. Glutathione peroxidase also increased in the liver, as did ascorbate in the plasma. These changes were not merely a consequence of exposure to low environmental temperatures. It is proposed that antioxidant defenses are increased in the IBAT of ground squirrels at the onset of hibernation in order to protect the tissue from reactive oxygen species generated as a result of the intense metabolic activity sustained by this tissue during reawakening.

引用

页码：407 / 413

页数：7

共 10 条

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