INHIBITORY EFFECTS OF POTENT INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOMEGALOVIRUS ON THE GROWTH OF HUMAN GRANULOCYTE-MACROPHAGE PROGENITOR CELLS-INVITRO

被引：10

作者：

SNOECK, R ^{[1
]}

LAGNEAUX, L ^{[1
]}

DELFORGE, A ^{[1
]}

BRON, D ^{[1
]}

VANDERAUWERA, P ^{[1
]}

STRYCKMANS, P ^{[1
]}

BALZARINI, J ^{[1
]}

DECLERCQ, E ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,CTR TUMEURS,INST JULES BORDET,SERV MED INTERNE,B-1000 BRUSSELS,BELGIUM

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1990年 / 9卷 / 08期

关键词：

D O I：

10.1007/BF01967220

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Phosphonoformate, ganciclovir, zidovudine and the novel acyclic nucleotide analogues (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were evaluated for their inhibitory effect on colony forming unit formation by human granulocyte-macrophage progenitor cells (obtained from 11 healthy volunteers) in vitro. The 50 % inhibitory dose of zidovudine, (S)-HPMPA, (S)-HPMPC, ganciclovir and phosphonoformate were 10.61, 16.55, 80.88, 41.02 and 668.64 μM, respectively, when the median-effect principle was applied. The bone marrow toxicity of zidovudine used at a low concentration (3.74 μM) was significantly decreased if the drug was combined with (S)-HPMPA, (S)-HPMPC or ganciclovir. If used at higher concentrations (74.90 μM), zidovudine showed increased myelotoxicity in the presence of (S)-HPMPA and ganciclovir, but not (S)-HPMPC. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

引用

页码：615 / 619

页数：5

共 16 条

[1]

BHALLA K, 1989, EXP HEMATOL, V17, P17

[2]

BUHLES WC, 1988, REV INFECT DIS S3, V10, P495

[3] QUANTITATIVE-ANALYSIS OF DOSE-EFFECT RELATIONSHIPS - THE COMBINED EFFECTS OF MULTIPLE-DRUGS OR ENZYME-INHIBITORS [J].

CHOU, TC ;

TALALAY, P .

ADVANCES IN ENZYME REGULATION, 1984, 22 :27-55

[4] 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) INHIBITS PROLIFERATION INVITRO OF HUMAN HEMATOPOIETIC PROGENITOR CELLS [J].

DAINIAK, N ;

WORTHINGTON, M ;

RIORDAN, MA ;

KRECZKO, S ;

GOLDMAN, L .

BRITISH JOURNAL OF HAEMATOLOGY, 1988, 69 (03) :299-304

[5]

DECLERCQ E, 1987, ANTIVIR RES, V8, P261

[6] A NOVEL SELECTIVE BROAD-SPECTRUM ANTI-DNA VIRUS AGENT [J].

DECLERCQ, E ;

HOLY, A ;

ROSENBERG, I ;

SAKUMA, T ;

BALZARINI, J ;

MAUDGAL, PC .

NATURE, 1986, 323 (6087) :464-467

[7]

DELFORGE A, 1983, SCAND J HAEMATOL, V31, P275

[8]

MATTHEWS T, 1988, REV INFECT DIS, V10, P490

[9] 3'-AZIDO-3'-DEOXYTHYMIDINE (BW A509U) - AN ANTIVIRAL AGENT THAT INHIBITS THE INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS INVITRO [J].

MITSUYA, H ;

WEINHOLD, KJ ;

FURMAN, PA ;

STCLAIR, MH ;

LEHRMAN, SN ;

GALLO, RC ;

BOLOGNESI, D ;

BARRY, DW ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7096-7100

[10] REPORT OF A WORKSHOP ON STANDARDIZATION OF SELECTIVE CULTURES FOR NORMAL AND LEUKEMIC-CELLS - INTERNATIONAL CANCER RESEARCH WORKSHOP PROGRAM (ICREW) [J].

MOORE, MAS ;

BURGESS, AW ;

METCALF, D ;

MCCULLOCH, EA ;

ROBINSON, WA ;

DICKE, KA ;

CHERVENICK, PA ;

BULL, JM ;

WU, AM ;

STANLEY, ER ;

GOLDMAN, J ;

TESTA, N .

BRITISH JOURNAL OF CANCER, 1977, 35 (04) :500-508

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