NONMUTAGENIC CARCINOGENS ARE PRIMARILY HYDROPHOBIC

被引：15

作者：

MCCOY, GD ^{[1
]}

ROSENKRANZ, HS ^{[1
]}

KLOPMAN, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

CARCINOGENESIS | 1990年 / 11卷 / 07期

关键词：

D O I：

10.1093/carcin/11.7.1111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal. © 1990 Oxford University Press.

引用

页码：1111 / 1117

页数：7

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