CYCLOCONDENSATION REACTION OF 1,2-DIAMINO-4-METHYLBENZENE AND P-SUBSTITUTED ACETOPHENONES

被引：18

作者：

INSUASTY, B

ABONIA, R

QUIROGA, J

MEIER, H

机构：

[1] UNIV MAINZ,INST ORGAN CHEM,W-6500 MAINZ,GERMANY

[2] UNIV ANDES,DEPT CHEM,BOGOTA,COLOMBIA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 01期

关键词：

D O I：

10.1002/jhet.5570300139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Diamino-4-methylbenzene 1 reacts in the presence of sulphuric acid with 4-substituted acetophenones 2a-e yielding 2,4-diaryl-2,3-dihydro-2,8-dimethyl-1H-1,5-benzodiazepines 3a-e and as minor component 2,4-diaryl-2,3-dihydro-2,7-dimethyl-1H-1,5-benzodiazepines 4a-e. The ratio 3:4 is in the range of 7:3. The structure determination of the regioisomers was performed by NOE measurements.

引用

页码：229 / 231

页数：3