REGULATION OF P42 AND P44 MAP KINASE ISOFORMS IN RAT-1 FIBROBLASTS STABLY TRANSFECTED WITH ALPHA(2)C10 ADRENOCEPTORS

被引：13

作者：

ANDERSON, NG ^{[1
]}

MILLIGAN, G ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT BIOCHEM,MOLEC PHARMACOL GRP,GLASGOW G12 8QQ,SCOTLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1624

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulation of Rat-1 fibroblasts, stably transfected with alpha(2)C10 receptors, with the specific alpha(2) agonist UK14304 led to the tyrosine phosphorylation and activation of the p42 and p44 isoforms of MAP kinase. Tyrosine phosphorylation of the MAP kinases was prevented by pertussis toxin. In unstimulated cells, there was constitutive tyrosine phosphorylation and activation of the p44 but not the p42 MAP kinase. This effect was not seen in non-transfected parental Rat-1 fibroblasts. (C) 1994 Academic Press, Inc.

引用

页码：1529 / 1535

页数：7

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