THE EFFICIENCY OF MALE-TO-FEMALE AND FEMALE-TO-MALE SEXUAL TRANSMISSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS - A STUDY OF 730 STABLE COUPLES

被引：191

作者：

NICOLOSI, A

LEITE, MLC

MUSICCO, M

ARICI, C

GAVAZZENI, G

LAZZARIN, A

ANGARANO, G

COSTIGLIOLA, P

GAFA, S

GASPARINI, M

GERVASONI, C

LUZZATI, R

MAGNANI, G

MORONI, M

PRISTERA, R

PUPPO, F

SALASSA, B

SARACCO, A

SINICCO, A

STELLINI, R

TIRELLI, U

TURBESSI, G

VIGEVANI, GM

ZERBONI, R

机构：

[1] Department of Epidemiology and Medical Informatics, Institute of Advanced Biomedical Technologies, National Research Council, Milan

[2] Gertrude H. Sergievsky Center, School of Public Health, Columbia University, New York, NY

[3] Division of Infectious Diseases, Ospedale di Bergamo, Bergamo

[4] Institute of Infectious Diseases, University of Milan, IRCCS Ospedale S. Raffaele, Milan

来源：

EPIDEMIOLOGY | 1994年 / 5卷 / 06期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS; AIDS; SEXUAL TRANSMISSION; SEXUAL BEHAVIOR; RISK FACTORS; INTERACTION; CONTRACEPTION;

D O I：

10.1097/00001648-199411000-00003

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To compare the efficiency of male-to-female and female-to-male sexual transmission of human immunodeficiency virus (HIV), we studied 524 female partners of HIV infected men and 206 male partners of HIV-infected women in 16 Italian clinical centers. All of the partners had had a sexual relarion ship with the index case lasting for at least 6 months and presented no other risk factor than sexual exposure to the HIV-infected partner. Among the 730 couples, 24% of the female partners were HIV positive, in comparison with 10% of the male partners. Using logistic regression analysis, including gender and controlling for condom use, frequency of intercourse, anal sex, partner's CD4(+) cell count and clinical stage, sexually transmitted diseases, genital infections, and contraceptive use, we found that the efficiency of male-to-female transmission was 2.3 (95% confidence interval = 1.1-4.8) times greater than that of female-to-male transmission. Between-gender differences in the contact surfaces and the intensity of exposure to HIV during sexual intercourse are possible reasons for the difference in efficiency of transmission.

引用

页码：570 / 575

页数：6

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