LONG CIRCULATING, CATIONIC LIPOSOMES CONTAINING AMINO-PEG-PHOSPHATIDYLETHANOLAMINE

被引：90

作者：

ZALIPSKY, S ^{[1
]}

BRANDEIS, E ^{[1
]}

NEWMAN, MS ^{[1
]}

WOODLE, MC ^{[1
]}

机构：

[1] GENTA INC,SAN DIEGO,CA 92121

来源：

FEBS LETTERS | 1994年 / 353卷 / 01期

关键词：

LIPOSOME; POLYETHYLENE GLYCOL; TARGETING; DNA;

D O I：

10.1016/0014-5793(94)01013-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ligand attachment to polyethylene glycol (PEG) grafted, long circulating liposomes at the polymer terminus is of interest for targeting but the effect of positively charged groups is unknown. Amino-polyethylene glycol-phosphatidylethanolamine (AminoPEG-PE), prepared in four steps from alpha-amino-omega-hydroxy-PEG, was tested for influence on liposome interactions in vivo: blood circulation and biodistribution. Despite surface amines on each liposome conferring cationic behavior, in vivo properties are comparable to those obtained with methoxy-PEG-PE. The consequences are profound for targeting and possibly systemic delivery of cationic lipidic-polynucleotide complexes.

引用

页码：71 / 74

页数：4

共 23 条

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