THE EARLY RISK OF MULTIPLE-SCLEROSIS AFTER OPTIC NEURITIS

被引：82

作者：

MILLER, DH

ORMEROD, IEC

MCDONALD, WI

MACMANUS, DG

KENDALL, BE

KINGSLEY, DPE

MOSELEY, IF

机构：

[1] INST NEUROL, QUEEN SQ, LONDON WC1N 3BG, ENGLAND

[2] NATL HOSP, LONDON WC1N 3BG, ENGLAND

[3] MOORFIELDS EYE HOSP, LONDON WC1V 7AN, ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1988年 / 51卷 / 12期

关键词：

D O I：

10.1136/jnnp.51.12.1569

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serial brain MRI was performed in 53 patients with clinically isolated optic neuritis. Using clinical and imaging evidence for relapse, multiple sclerosis developed within a mean of 12 months in 19 of 34 cases (56%) with brain lesions at presentation, and in only 3 of 19 cases (16%) without (Relative Risk = 6.8, p < 0.005).

引用

收藏

页码：1569 / 1571

页数：3

相关论文

共 17 条

[11] SILENT BRAIN-LESIONS IN PATIENTS WITH ISOLATED IDIOPATHIC OPTIC NEURITIS - A CLINICAL AND NUCLEAR-MAGNETIC-RESONANCE IMAGING STUDY [J].

JACOBS, L ;

KINKEL, PR ;

KINKEL, WR .

ARCHIVES OF NEUROLOGY, 1986, 43 (05) :452-455

[12] PROGNOSIS OF OPTIC NEURITIS WITH SPECIAL REFERENCE TO CEREBROSPINAL-FLUID IMMUNOGLOBULINS AND MEASLES-VIRUS ANTIBODIES [J].

NIKOSKELAINEN, E ;

FREY, H ;

SALMI, A .

ANNALS OF NEUROLOGY, 1981, 9 (06) :545-550

[13] DISSEMINATED LESIONS AT PRESENTATION IN PATIENTS WITH OPTIC NEURITIS [J].

ORMEROD, IEC ;

MCDONALD, WI ;

DUBOULAY, GH ;

KENDALL, BE ;

MOSELEY, IF ;

HALLIDAY, AM ;

KAKIGI, R ;

KRISS, A ;

PERINGER, E .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1986, 49 (02) :124-127

[14] THE ROLE OF NMR IMAGING IN THE ASSESSMENT OF MULTIPLE-SCLEROSIS AND ISOLATED NEUROLOGICAL LESIONS - A QUANTITATIVE STUDY [J].

ORMEROD, IEC ;

MILLER, DH ;

MCDONALD, WI ;

DUBOULAY, EPGH ;

RUDGE, P ;

KENDALL, BE ;

MOSELEY, IF ;

JOHNSON, G ;

TOFTS, PS ;

HALLIDAY, AM ;

BRONSTEIN, AM ;

SCARAVILLI, F ;

HARDING, AE ;

BARNES, D ;

ZILKHA, KJ .

BRAIN, 1987, 110 :1579-1616

[15]

Perkin GD., 1979, OPTIC NEURITIS ITS D

[16] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[17]

SVEJGAARD A, 1975, MONOGRAPHS HUMAN GEN, P1