ADMINISTRATION OF TESTOSTERONE ALLEVIATES THE CONSTITUTIVE SEX DIFFERENCE IN RAT-BRAIN CYTOCHROME-P-450

被引：7

作者：

ANANDATHEERTHAVARADA, HK ^{[1
]}

RAVINDRANATH, V ^{[1
]}

机构：

[1] NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROCHEM,POB 2900,BANGALORE 560029,KARNATAKA,INDIA

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 02期

关键词：

SEX-RELATED; BRAIN; CYTOCHROME-P-450; TESTOSTERONE; MONO-OXYGENASE;

D O I：

10.1016/0304-3940(91)90038-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sex-related difference was observed in the levels of total cytochrome P-450 (P-450) and the mono-oxygenase activity mediated by P-450(b,e), namely, aminopyrine N-demethylase and morphine N-demethylase activity in rat brain microsomes. Male rat brain had higher activity of the above enzymes as compared to the female rat brain. On the other hand, P-450(c,d) mediated 7-ethoxycoumarin O-deethylase and benzo(a)pyrene hydroxylase activity showed no sex-related difference in rat brain. Administration of testosterone elevated the levels of total P-450, aminopyrine N-demethylase and morphine N-demethylase in female rat brain to levels comparable with that of the male rat brain. No significant change was observed in the levels of 7-ethoxycoumarin O-deethylase and benzo(a)pyrene hydroxylase and NADPH cytochrome c reductase. All of the above enzyme levels were unaffected in the male rat brain following the treatment with testosterone. These results indicate that testosterone may regulate the forms of cerebral P-450 that are associated with the sex-related difference observed in rat brain.

引用

页码：238 / 240

页数：3

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