A MEMBER OF THE CHICKEN RXR FAMILY OF NUCLEAR RECEPTORS ACTIVATES TRANSCRIPTION IN RESPONSE TO RETINOIC ACID

被引：9

作者：

EAGER, NSC ^{[1
]}

ROWE, A ^{[1
]}

BRICKELL, PM ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT BIOCHEM & MOLEC BIOL,MED MOLEC BIOL UNIT,WINDEYER BLDG,LONDON W1P 6DB,ENGLAND

来源：

FEBS LETTERS | 1991年 / 292卷 / 1-2期

基金：

英国惠康基金;

关键词：

RETINOIC ACID; RETINOIC ACID RECEPTOR; RXR; TRANSCRIPTIONAL CONTROL; TRANSACTIVATION;

D O I：

10.1016/0014-5793(91)80844-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chicken cRXR nuclear receptor is a member of the steroid/thyroid hormone receptor superfamily. In this paper we show that cRXR can transactivate gene expression in response to retinoic acid, but that its sensitivity to retinoic acid is lower than that of the hRAR-beta receptor. We have also compared the ability of cRXR and hRAR-beta to respond to a panel of other retinoids. Unlike hRAR-beta, cRXR failed to respond to the naturally occurring retinoid 3,4-didehydro-retinoic acid or to the synthetic retinoid TTNPB, both of which share the ability of retinoic acid to induce digit duplications when locally applied to chick limb buds.

引用

页码：103 / 106

页数：4

共 20 条

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