CAPSULAR TYPES OF VIBRIO-VULNIFICUS - AN ANALYSIS OF STRAINS FROM CLINICAL AND ENVIRONMENTAL SOURCES

被引：60

作者：

HAYAT, U

REDDY, GP

BUSH, CA

JOHNSON, JA

WRIGHT, AC

MORRIS, JG

机构：

[1] VET AFFAIRS MED CTR,INFECT DIS SECT,10 N GREENE ST,BALTIMORE,MD 21201

[2] UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201

[3] UNIV MARYLAND,DEPT CHEM & BIOCHEM,BALTIMORE,MD 21201

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 168卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1093/infdis/168.3.758

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vibrio vulnificus produces a capsular polysaccharide (CPS) that is essential for virulence. CPS from V. vulnificus clinical strain MO6-24 has been purified and the structure determined. In preliminary screening with antisera raised to MO6-24 CPS, 4 (19%) of 21 clinical isolates (including MO6-24), but none of 67 environmental V. vulnificus isolates, agglutinated with anti-MO6-24 antisera (P = .003). CPS was isolated from a subset of 12 clinical and 7 environmental isolates and analyzed by high-performance anion-exchange chromatography and one-dimensional nuclear magnetic resonance. MO6-24 and 1 other serologically positive strain had identical CPS structures; the other 2 serologically positive strains had substitutions in two of four sugar residues. Thirteen other capsular types were identified among the remaining 15 strains from which CPS was extracted.

引用

页码：758 / 762

页数：5

共 15 条

[1] ANTIBODIES TO POLY[(2-]8)-ALPHA-N-ACETYLNEURAMINIC ACID] AND POLY[(2-]9)-ALPHA-N-ACETYLNEURAMINIC ACID] ARE ELICITED BY IMMUNIZATION OF MICE WITH ESCHERICHIA-COLI K92 CONJUGATES - POTENTIAL VACCINES FOR GROUP-B AND GROUP-C MENINGOCOCCI AND ESCHERICHIA-COLI K1 [J].