ADHESIVE PROPERTIES OF CHORIOCARCINOMA CELLS TOWARD LYMPHOCYTES ACTIVATED OR NOT BY INTERLEUKIN-2

被引:14
作者
JAROUSSEAU, AC
THIBAULT, G
REVERDIAU, P
RODRIGUEZ, AM
LACORD, M
DERUSSE, J
WATIER, H
DEGENNE, D
LEBRANCHU, Y
GRUEL, Y
LEBOUTEILLER, P
BARDOS, P
机构
[1] INSERM,U395,F-31024 TOULOUSE,FRANCE
[2] FAC MED TOURS,HEMATOL LAB,F-37032 TOURS,FRANCE
关键词
D O I
10.1006/cimm.1994.1203
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Choriocarcinoma cells (CC) in vitro are resistant to NK lysis but sensitive to lysis by blood or decidual effecters activated by interleukin-2 (IL-2). Because lytic activity requires a step of adhesion, the adhesive properties of the choriocarcinoma cells BeWo, JEG-3, and JAR were examined functionally toward peripheral blood lymphocytes. The adhesion of lymphocytes to choriocarcinoma cells was very low and did not increase after stimulating lymphocytes with IL-2. As demonstrated by cytofluorimetry analysis, choriocarcinoma cells and cytotrophoblast cells prepared from term placenta expressed intercellular adhesion molecule-1 (ICAM-1), whereas only CC expressed CD56. Tumor necrosis factor-alpha or interferon-gamma increased the expression of ICAM-1 on choriocarcinoma cells without modifying the adhesion of lymphocytes to choriocarcinoma cells. These results suggest that resistance of choriocarcinoma cells to lysis by cytotoxic effecters could partially be attributed to the low level of lymphocyte adhesion to these cells. (C) 1994 Academic Press, Inc.
引用
收藏
页码:38 / 47
页数:10
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