ADDITIONAL ANTITUMOR ECTEINASCIDINS FROM A CARIBBEAN TUNICATE - CRYSTAL-STRUCTURES AND ACTIVITIES INVIVO

被引：158

作者：

SAKAI, R

RINEHART, KL

GUAN, Y

WANG, AHJ

机构：

[1] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801

[2] UNIV ILLINOIS,DEPT CELL & STRUCT BIOL,URBANA,IL 61801

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 23期

关键词：

D O I：

10.1073/pnas.89.23.11456

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N-12-formyl derivative of Et 729 and the natural N-12 -oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.

引用

页码：11456 / 11460

页数：5

共 25 条

[1]

ARAI T, 1979, TETRAHEDRON LETT, P2355

[2]

ARORA SK, 1991, J BIOMOL STRUCT DYN, V6, P489

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