ROLE OF PROTEIN OXIDATION IN AGING AND IN AGE-ASSOCIATED NEURODEGENERATIVE DISEASES

被引：47

作者：

CARNEY, JM ^{[1
]}

CARNEY, AM ^{[1
]}

机构：

[1] ST PAULS SCH,CONCORD,NH 03301

来源：

LIFE SCIENCES | 1994年 / 55卷 / 25-26期

关键词：

ALZHEIMERS DISEASE; AGING AB PEPTIDES; FREE RADICALS;

D O I：

10.1016/0024-3205(94)00390-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aging and age-associated neurodegenerative diseases have been proposed to be the result of changes in a in anti-oxidant status and in the production of reactive oxygen species. Studies in humans have demonstrated a significant increase in oxidized protein from brains of neurological normals and from individuals with different neurological diseases (Alzheimer's, Parkinson's and Huntington's Disease). Preclinical models of these conditions and of cerebral ischemia demonstrate the primary role of protein oxidation in the initial steps of these neurodegenerative diseases. Aging is a risk factor in the development of these diseases and is also associated with a decrease in the anti-oxidant defense systems of the brain. It is proposed that free radicals play a primary role in the initiation of those biochemical events that ultimately lead to the death of the neuron.

引用

页码：2097 / 2103

页数：7

共 25 条

[1] ALTERNATIVE EXCITOTOXIC HYPOTHESES [J].