EPINEPHRINE INFUSION IN SHEEP - SYSTEMIC AND RENAL HEMODYNAMIC-EFFECTS

Objective: To evaluate the dose-response effects of graded epinephrine infusions on systemic and renal hemodynamics. Design: Prospective, dose-response study. Setting: Laboratory at a university hospital. Subjects: Thirteen conscious, chronically catheterized, adult merino sheep. Interventions: Ten sheep received five infusions of epinephrine (5, 10, 20, and 40 mu g/min; the 40-mu g/min dose was repeated) and a placebo (saline) on separate days (at least 1 day apart). Each drug infusion was administered for 4 hrs on separate days after a 90-min baseline was established. Plasma catecholamine values and renin activity were measured in an additional three sheep infused with 40 mu g/min epinephrine. Measurements and Main Results: Renal blood flow was measured, using an electromagnetic flow transducer; these data, along with aortic and pulmonary arterial pressure, were continuously recorded after analog-to-digital conversion. Cardiac output was intermittently measured by thermodilution. Epinephrine resulted in a dose-dependent increase in mean arterial pressure (p <.001), and in cardiac output at 30, 60, and 120 mins after the start of the infusion. Concurrently, systemic vascular resistance was initially depressed below baseline, but then gradually increased during the 4-hr infusion period. Although a dose-dependent increase in renal vascular resistance was found, 5- and 10-mu g/min of epinephrine failed to alter renal vascular resistance. However, 20- and 40-mu g/min of epinephrine increased renal vascular resistance by 77% and 94% respectively, at 10 mins, but these values decreased to 17% and 16% of baseline by 120 mim. Consequently, an early dose-dependent decrease in renal blood flow was also time dependent, with renal blood flow increasing back to or above baseline at all studied infusion rates of epinephrine. Conclusions: Using a clinically relevant dose regimen, epinephrine increased mean arterial pressure and cardiac output. Penal blood flow decreased transiently, but returned to baseline within 30 to 60 mins.