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DEVELOPMENT OF AN INVITRO MODEL OF TUMOR PROGRESSION USING V-RAF AND V-RAF/V-MYC TRANSFORMED RAT-LIVER EPITHELIAL-CELLS - CORRELATION OF TUMORIGENICITY WITH THE DOWN-REGULATION OF SPECIFIC PROTEINS
被引:22
作者
:
WORLAND, PJ
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
WORLAND, PJ
[
1
]
HAMPTON, LL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
HAMPTON, LL
[
1
]
THORGEIRSSON, SS
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
THORGEIRSSON, SS
[
1
]
HUGGETT, AC
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
HUGGETT, AC
[
1
]
机构
:
[1]
NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892
来源
:
MOLECULAR CARCINOGENESIS
|
1990年
/ 3卷
/ 01期
关键词
:
epithelial cell transformation;
Key words;
liver carcinogenesis;
oncogenes;
Two‐dimensional gel electrophoresis;
D O I
:
10.1002/mc.2940030107
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
A series of clonal cell lines were derived from rat liver epithelial cells after being infected with a defective retrovirus containing either v‐raf (3611‐MSV) or v‐raf/v‐myc(J2) together with a helper virus. These clones exhibited a different morphology from the regular cuboid shape of the control cells, infected only with the helper virus. All of the infected cell lines contained at least one full length copy of appropriate proviral DNA and expressed comparable levels of v‐raf mRNA, although only the cells transformed with the v‐raf/v‐myc combination were capable of anchorage‐independent growth in soft agar. All of the clones except the controls formed tumors in nude mice but with markedly different latency periods and growth rates. Thus, these cell lines represent an in vitro model for tumor progression. Two‐dimensional polyacrylamide electrophoresis was used to investigate changes in cellular protein expression related to malignant conversion. The expression of three proteins of pl/Mr × 10−3 5.9‐7.2/205 (RP1), 6.5‐7.5/160 (RP2) and 4.0/85 (RP3) consistently matched the transformed phenotype. In particular the expression of RP1 and RP2 correlated with the relative tumorigenicity of the cell lines. Rat liver epithelial cell lines transformed by other protocols that did not involve v‐raf also showed downregulation of these three polypeptides. Crude fractionation studies determined RP1 to be soluble and RP2 and RP3 to be membrane associated. RP2 was shown to be a glycoprotein containing mannose and galactose residues. These three proteins are consistent markers for the tumorigenic potential of rat liver epithelial cells. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:20 / 29
页数:10
相关论文
共 43 条
[1]
BEER DG, 1988, CANCER RES, V48, P1610
[2]
BRAUN L, 1987, CANCER RES, V47, P4116
[3]
CAMERON R, 1978, CANCER RES, V38, P823
[4]
NUMBER AND EVOLUTIONARY CONSERVATION OF ALPHA-TUBULIN AND BETA-TUBULIN AND CYTOPLASMIC BETA-ACTIN AND GAMMA-ACTIN GENES USING SPECIFIC CLONED CDNA PROBES
CLEVELAND, DW
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
CLEVELAND, DW
LOPATA, MA
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
LOPATA, MA
MACDONALD, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
MACDONALD, RJ
COWAN, NJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
COWAN, NJ
RUTTER, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
RUTTER, WJ
KIRSCHNER, MW
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
KIRSCHNER, MW
[J].
CELL,
1980,
20
(01)
: 95
-
105
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INTERACTION BETWEEN RAF AND MYC ONCOGENES IN TRANSFORMATION INVIVO AND INVITRO
CLEVELAND, JL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
CLEVELAND, JL
JANSEN, HW
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
JANSEN, HW
BISTER, K
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
BISTER, K
FREDRICKSON, TN
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
FREDRICKSON, TN
MORSE, HC
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
MORSE, HC
IHLE, JN
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
IHLE, JN
RAPP, UR
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
RAPP, UR
[J].
JOURNAL OF CELLULAR BIOCHEMISTRY,
1986,
30
(03)
: 195
-
218
[6]
SUPPRESSION OF TROPOMYOSIN SYNTHESIS, A COMMON BIOCHEMICAL FEATURE OF ONCOGENESIS BY STRUCTURALLY DIVERSE RETROVIRAL ONCOGENES
COOPER, HL
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
COOPER, HL
FEUERSTEIN, N
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
FEUERSTEIN, N
NODA, M
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
NODA, M
BASSIN, RH
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
BASSIN, RH
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1985,
5
(05)
: 972
-
983
[7]
EVARTS RP, 1989, CANCER RES, V49, P1541
[8]
A PRECURSOR PRODUCT RELATIONSHIP EXISTS BETWEEN OVAL CELLS AND HEPATOCYTES IN RAT-LIVER
EVARTS, RP
论文数:
0
引用数:
0
h-index:
0
EVARTS, RP
NAGY, P
论文数:
0
引用数:
0
h-index:
0
NAGY, P
MARSDEN, E
论文数:
0
引用数:
0
h-index:
0
MARSDEN, E
THORGEIRSSON, SS
论文数:
0
引用数:
0
h-index:
0
THORGEIRSSON, SS
[J].
CARCINOGENESIS,
1987,
8
(11)
: 1737
-
1740
[9]
FARBER E, 1956, CANCER RES, V16, P142
[10]
GLUTATHIONE AND GAMMA GLUTAMYL TRANSPEPTIDASE IN RAT-LIVER DURING CHEMICAL CARCINOGENESIS
FIALA, S
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
FIALA, S
MOHINDRU, A
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
MOHINDRU, A
KETTERING, WG
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
KETTERING, WG
FIALA, AE
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
FIALA, AE
MORRIS, HP
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
MORRIS, HP
[J].
JOURNAL OF THE NATIONAL CANCER INSTITUTE,
1976,
57
(03)
: 591
-
598
←
1
2
3
4
5
→
共 43 条
[1]
BEER DG, 1988, CANCER RES, V48, P1610
[2]
BRAUN L, 1987, CANCER RES, V47, P4116
[3]
CAMERON R, 1978, CANCER RES, V38, P823
[4]
NUMBER AND EVOLUTIONARY CONSERVATION OF ALPHA-TUBULIN AND BETA-TUBULIN AND CYTOPLASMIC BETA-ACTIN AND GAMMA-ACTIN GENES USING SPECIFIC CLONED CDNA PROBES
CLEVELAND, DW
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
CLEVELAND, DW
LOPATA, MA
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
LOPATA, MA
MACDONALD, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
MACDONALD, RJ
COWAN, NJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
COWAN, NJ
RUTTER, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
RUTTER, WJ
KIRSCHNER, MW
论文数:
0
引用数:
0
h-index:
0
机构:
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
PRINCETON UNIV, DEPT BIOCHEM SCI, PRINCETON, NJ 08540 USA
KIRSCHNER, MW
[J].
CELL,
1980,
20
(01)
: 95
-
105
[5]
INTERACTION BETWEEN RAF AND MYC ONCOGENES IN TRANSFORMATION INVIVO AND INVITRO
CLEVELAND, JL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
CLEVELAND, JL
JANSEN, HW
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
JANSEN, HW
BISTER, K
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
BISTER, K
FREDRICKSON, TN
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
FREDRICKSON, TN
MORSE, HC
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
MORSE, HC
IHLE, JN
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
IHLE, JN
RAPP, UR
论文数:
0
引用数:
0
h-index:
0
机构:
NCI,FREDERICK CANC RES FACIL,LITTON BIONET INC,BASIC RES PROGRAM,FREDERICK,MD 21701
RAPP, UR
[J].
JOURNAL OF CELLULAR BIOCHEMISTRY,
1986,
30
(03)
: 195
-
218
[6]
SUPPRESSION OF TROPOMYOSIN SYNTHESIS, A COMMON BIOCHEMICAL FEATURE OF ONCOGENESIS BY STRUCTURALLY DIVERSE RETROVIRAL ONCOGENES
COOPER, HL
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
COOPER, HL
FEUERSTEIN, N
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
FEUERSTEIN, N
NODA, M
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
NODA, M
BASSIN, RH
论文数:
0
引用数:
0
h-index:
0
机构:
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
KEIO UNIV,SCH MED,DEPT MICROBIOL,TOKYO 160,JAPAN
BASSIN, RH
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1985,
5
(05)
: 972
-
983
[7]
EVARTS RP, 1989, CANCER RES, V49, P1541
[8]
A PRECURSOR PRODUCT RELATIONSHIP EXISTS BETWEEN OVAL CELLS AND HEPATOCYTES IN RAT-LIVER
EVARTS, RP
论文数:
0
引用数:
0
h-index:
0
EVARTS, RP
NAGY, P
论文数:
0
引用数:
0
h-index:
0
NAGY, P
MARSDEN, E
论文数:
0
引用数:
0
h-index:
0
MARSDEN, E
THORGEIRSSON, SS
论文数:
0
引用数:
0
h-index:
0
THORGEIRSSON, SS
[J].
CARCINOGENESIS,
1987,
8
(11)
: 1737
-
1740
[9]
FARBER E, 1956, CANCER RES, V16, P142
[10]
GLUTATHIONE AND GAMMA GLUTAMYL TRANSPEPTIDASE IN RAT-LIVER DURING CHEMICAL CARCINOGENESIS
FIALA, S
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
FIALA, S
MOHINDRU, A
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
MOHINDRU, A
KETTERING, WG
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
KETTERING, WG
FIALA, AE
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
FIALA, AE
MORRIS, HP
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,CELL PHYSIOL LAB,LOS ANGELES,CA 90073
MORRIS, HP
[J].
JOURNAL OF THE NATIONAL CANCER INSTITUTE,
1976,
57
(03)
: 591
-
598
←
1
2
3
4
5
→