OCTAPEPTIDE ANALOGS OF SOMATOSTATIN INHIBIT THE CLONAL GROWTH AND VASOACTIVE INTESTINAL PEPTIDE-STIMULATED CYCLIC-AMP FORMATION IN HUMAN SMALL-CELL LUNG-CANCER CELLS

被引：27

作者：

TAYLOR, JE ^{[1
]}

MOREAU, JP ^{[1
]}

BAPTISTE, L ^{[1
]}

MOODY, TW ^{[1
]}

机构：

[1] GEORGE WASHINGTON UNIV,SCH MED & HLTH SCI,DEPT BIOCHEM & MOLEC BIOL,WASHINGTON,DC 20037

来源：

PEPTIDES | 1991年 / 12卷 / 04期

关键词：

SOMATOSTATIN; SRIF; SMALL CELL LUNG CANCER; SOMATOSTATIN RECEPTORS; VASOACTIVE INTESTINAL PEPTIDE; CYCLIC AMP;

D O I：

10.1016/0196-9781(91)90143-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two endocrinologically active octapeptide analogues (BIM-23014 C and BIM-23034) of somatostatin (SRIF) containing either an N- or C-terminal 3-(2-naphthyl)-D-Ala residue were examined for their ability to inhibit the in vitro receptor binding, clonal growth, and vasoactive intestinal peptide (VIP)-stimulated cyclic AMP formation in human small cell lung cancer cell (SCLC) line NCI-H345. Both SRIF peptides inhibited [I-125]SRIF(Tyr11)-14 binding with IC50 values in the low nM range. Colony formation in the in vitro SCLC growth assay was also inhibited in the same concentration range, as was VIP-stimulated cyclic AMP formation. Therefore, octapeptide analogues of SRIF function as SCLC SRIF receptor agonists.

引用

页码：839 / 843

页数：5

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