REMARKABLY ENHANCED EXPRESSION OF THE TYPE-II HEXOKINASE IN RAT HEPATOMA-CELL LINE AH130

被引：46

作者：

SHINOHARA, Y ^{[1
]}

ICHIHARA, J ^{[1
]}

TERADA, H ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,SHOMACHI 1,TOKUSHIMA 770,JAPAN

来源：

FEBS LETTERS | 1991年 / 291卷 / 01期

关键词：

ASCITES HEPATOMA (AH130); NORTHERN BLOTTING; HEXOKINASE ISOZYME; TISSUE SPECIFIC EXPRESSION;

D O I：

10.1016/0014-5793(91)81102-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of mRNAs encoding hexokinase isozymes was studied in various cells such as rat brain, liver, skeletal muscle, kidney and heart, and the rat hepatoma cell line AH130 by Northern blotting. High specific expression of type II hexokinase was observed only with AH130 cells. In contrast, specific expression of type I hexokinase was detected in energy-requiring normal tissue cells such as brain and heart. These results suggest that the expression of hexokinase isozyme in the tumor cells is different from that in normal cells.

引用

页码：55 / 57

页数：3

共 14 条

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