EFFECTS OF MORPHINE - AN ELECTROPHYSIOLOGICAL STUDY ON GUINEA-PIG PAPILLARY-MUSCLE

被引：9

作者：

ALARCON, S ^{[1
]}

HERNANDEZ, J ^{[1
]}

LAORDEN, ML ^{[1
]}

机构：

[1] UNIV MURCIA,DEPT PHYSIOL & PHARMACOL,MURCIA,SPAIN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03601.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracellular microelectrodes were used to study the electrophysiological effects of morphine on guinea-pig papillary muscle. Morphine (5 x 10(-4) M) caused a significant decrease in the maximum rate of depolarization. At high concentrations (5 x 10(-3) M) morphine induced a decrease in the action potential amplitude and a prolongation of the action potential duration. The administration of naloxone (10(-7) M) partially antagonized the cardiac electrophysiological effects of morphine. These results suggest that the electrophysiological effects of morphine may be due to an interaction with opioid receptors.

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页码：275 / 277

页数：3

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