THE NATURAL INTERLEUKIN-1 RECEPTOR ANTAGONIST PREVENTS INTERLEUKIN-1-INDUCED PRETERM DELIVERY IN MICE

被引:186
作者
ROMERO, R
TARTAKOVSKY, B
机构
[1] NICHHD,PERINATOL BRANCH,BETHESDA,MD 20892
[2] WEIZMANN INST SCI,DEPT IMMUNOL,IL-76100 REHOVOT,ISRAEL
关键词
INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; PRETERM LABOR; PREMATURITY; CHORIOAMNIONITIS;
D O I
10.1016/S0002-9378(12)80035-4
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVES: Interleukin-1 has been implicated in the mechanisms responsible for preterm parturition in the setting of intrauterine infection. This cytokine is produced by human decidua, stimulates prostaglandin production by intrauterine tissues, and induces preterm parturition in mice. The purpose of this study was to determine whether pretreatment with the natural interleukin-1 receptor antagonist can block interleukin-1-induced preterm parturition in mice. STUDY DESIGN: Balb/CJ female mice impregnated by B6D2 F-1 male mice were randomly allocated to one of the following treatment groups: (1) saline solution (n = 15), (2) human recombinant interleukin-1alpha or human recombinant interleukin-1beta (n = 12), (3) human recombinant interleukin-1 receptor antagonist (n = 13), and (4) human recombinant interleukin-1 receptor antagonist plus human recombinant interleukin-1 (n = 24). RESULTS: An interleukin-1 dose of 10 mug per mouse induced preterm parturition in all cases. Pretreatment with interleukin-1 receptor antagonist (dose 1 mg per animal) prevented interleukin-1-induced preterm parturition. Interleukin-1 receptor antagonist administration was not associated with demonstrable side effects including behavioral changes, vaginal bleeding, duration of pregnancy, and pregnancy outcome. CONCLUSION: Our results suggest that interleukin-1-induced preterm delivery in mice is mediated by the interleukin-1 receptor.
引用
收藏
页码:1041 / 1045
页数:5
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